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便携式实时PCR&微芯片上的电化学实时聚合酶链式反应
项目编号: 状态:已结束 联系方式:
发布时间:2013/5/6来源:本站 我要咨询 T:
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香港科技大学项目介绍(二)

香港科技大学技术转移中心简介:
香港科技大學屬下的技術轉移中心和香港科大研究開發有限公司致力締結大學與業界之間的合作,建立研發合作夥伴關係,推動知識產權的保護和授權工作,並培育創業公司。
The HKUST Technology Transfer Center (TTC) and HKUST R and D Corporation Ltd (RDC) work to establish university-industry collaboration, R&D partnerships, protection and licensing of intellectual property, and incubate

项目联系方式:0755-86358710, 电子邮箱:dzn@sotcbb.com

项目名称:便携式实时PCR
     微芯片上的电化学实时聚合酶链式反应

发明简介
(TTC.PA.0314)
目前市售的聚合酶链式反应(PCR)仪器是基于光学检测手段,普遍非常庞大和昂贵。本发明突破性地用电化学测量手段替代了传统的光学测量手段,从而同时解决了设备的体积和成本问题,并且为多通道实时PCR提供了可能,而这些是传统的基于光学设备难以做到的。

本发明的突性是电活性报告基因在电极表面的循环积累,从而使信号增强,以测定一个特定热循环中的PCR扩增子数量。

市场前景
相比传统的巨大复杂的采用光学手段的仪器,本发明采用电化学手段,使得设备简单小巧。本技术的市场涵盖科学研究、临床诊断、环境监测、食品检测和生物防御等领域。

合作方式包括:
技术许可:现有技术已经足以用来开发第一代商业化产品。
合作研发:我们正致力于从多个方面进一步改善本技术。相关的研究工作正在进行中。

技术亮点
• 设备简单、具成本效益
• 实时检测
• 高检测速率
• 准确
• 便携
• 动态测量范围大


“便携式实时PCR”项目英文介绍
NAME:PORTABLE REAL-TIME PCR
Electrochemistry-based real-time PCR on a microchip

INVENTION
(TTC.PA.0314)
Current commercial real-time polymerase chain reaction (PCR) instruments are usually based on optical detection methods and are therefore very bulky and expensive. The breakthrough of this invention is the use of an electrochemistry-based method to perform quantitative real-time PCR instead of fluorescence-based optical techniques. It addresses both the issues of system volume and cost, and would also provide possibility for multiplex real-time PCR, which is a difficult process to do in an optics-based counterpart.

The most prominent feature of this invention is the cycle-by-cycle accumulation of electroactive reporters on the electrode surface that would lead to the signal increase, which could be used to quantify the amount of PCR amplicons produced at a specific thermal cycle.

MARKET OPPORTUNITY
This electrochemical approach utilizes simple and miniaturizable instrumentation compared to the bulky and sophisticated optics required in the fluorescence-based schemes. Market of this new technology will cover scientific research, clinical diagnostics, environmental monitoring, food testing and biodefense applications.

Collaboration opportunities include:
• Technology licensing: The current technology should be sufficient to develop the commercial product of the first generation.
• Collaborative research and development: Progress has been made to improve the technology in various aspects. Research work on the invention is on-going.

HIGHLIGHT OF THE TECHNOLOGY
• Simple instrumentation and cost effective
• Real-time, accurate, portable
• High throughput
• Wide dynamic range of quantification
 [Thermochromic Smart Window]

 

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